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Filtered Search Results
Medchemexpress LLC Slm6031434 hydrochloride | 1897379-34-8 | 99.1% | 1 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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A selective sphingosine kinase 2 (SphK2) inhibitor supplied as the hydrochloride salt for research use. Solid, high-purity material characterized by molecular formula C22H31ClF3N5O2 and molecular weight 489.96 Da.
- Selective sphingosine kinase 2 inhibitor for biochemical and cellular studies.
- Hydrochloride salt form, supplied as a solid powder.
- High purity (reported 99.1%), suitable for research applications.
- Soluble in water at approximately 40 mg/mL with ultrasonic warming if required.
- Recommended storage: long-term in solvent at -80°C, short-term at -20°C, sealed and away from moisture.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Melitracen hydrochloride | 10563-70-9 | MFCD00242905 | >98.0% | 327.89 | C21H26ClN | 200 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Melitracen hydrochloride is a research-grade tricyclic antidepressant hydrochloride salt supplied for laboratory use. It is used in pharmacological studies of monoamine neurotransmitter uptake and serotonergic (5-HT) receptor pathways. Provided as a solid for in vitro and preclinical research; not for human or veterinary use.
- Tricyclic antidepressant hydrochloride salt.
- Molecular formula C21H26ClN.
- Molecular weight 327.89.
- Purity >98.0% (HPLC).
- Available as a solid powder, commonly in 200 MG quantities.
- For research use only; not for human or veterinary use.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Ponatinib hydrochloride | 1114544-31-8 | 99.8% | 569.02 | 25 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Ponatinib hydrochloride, also known as AP24534 hydrochloride, is an orally active multi-targeted kinase inhibitor. It inhibits various kinases with IC50s including 0.37 nM for Abl, 1.1 nM for PDGFRα, 1.5 nM for VEGFR2, 2.2 nM for FGFR1, and 5.4 nM for Src.
- Purity of 99.76%
- CAS number: 1114544-31-8
- Molecular weight: 569.02
- Appears as an off-white to light yellow solid
- Soluble in DMSO at 25 mg/mL
- Targets Bcr-Abl, FGFR, PDGFR, VEGFR, Src, and Autophagy pathways
- Store at 4°C, sealed, away from moisture; in solvent, store at -80°C for 6 months or -20°C for 1 month
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC PhiKan 083 hydrochloride | 1050480-30-2 | 99.3% | 274.79 | 10 MG
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PhiKan 083 hydrochloride is a carbazole derivative designed to bind to the surface cavity and stabilize the Y220C p53 mutant, with a binding affinity (Kd) of 167 μM. It effectively slows down the thermal denaturation rate of the p53 mutant and has been shown to reduce cell viability in engineered variants of Ln229 cells. When used in combination with NSC 123127, it enhances pro-apoptotic activity across multiple Ln229 cell variants.
- Binds to and stabilizes Y220C p53 mutant
- Slows down thermal denaturation rate of p53 mutant
- Reduces cell viability in engineered variants of Ln229 cells
- Enhances pro-apoptotic activity when combined with NSC 123127
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Medchemexpress LLC Cl-amidine hydrochloride | 1373232-26-8 | MFCD22201084 | 99.8% | 347.24 | C14H20Cl2N4O2 | 1 ML
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Cl-amidine hydrochloride is an orally active peptidylarginine deiminase (PAD) inhibitor used in biochemical, cellular, and in vivo research to block protein citrullination and probe PAD-related pathways.
- Inhibits PAD1, PAD3, and PAD4 with reported IC50 values of 0.8 μM, 6.2 μM, and 5.9 μM.
- Available as a 10 mM solution in DMSO or as solid quantities for formulation flexibility.
- High purity (~99.8%) suitable for biochemical and cellular assays.
- Demonstrated activity in cell apoptosis and neutrophil extracellular trap formation assays.
- Shows efficacy in murine models of colitis and sepsis in published studies.
- Provided supporting documents: data sheet, SDS, COA, HNMR, RP-HPLC, and LCMS.
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Medchemexpress LLC Tiaramide hydrochloride | 35941-71-0 | MFCD01702832 | 98.7% | 392.30 | C15H19Cl2N3O3S | 5 MG
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Tiaramide hydrochloride is the hydrochloride salt of tiaramide, an analgesic research compound provided in milligram quantities for laboratory use. It is a light yellow solid with molecular formula C15H19Cl2N3O3S and molecular weight 392.30 g·mol-1. Typical purity is 98.7%, and the compound is commonly handled in DMSO for in vitro and pharmacological studies.
- Hydrochloride salt form for improved stability
- High purity (approximately 98.7%)
- Available in milligram-scale sizes for research use
- Light yellow solid suitable for analytical testing
- Soluble in DMSO for biological assays
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Medchemexpress LLC BMY-14802 hydrochlo | 10 MG
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BMY-14802 hydrochlo | 10 MG
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Medchemexpress LLC GW806742X hydrochloride | 98.3% | 610.01 | 25 MG
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GW806742X hydrochloride is an ATP mimetic and a potent MLKL inhibitor that binds the MLKL pseudokinase domain with a Kd of 9.3 μM. It also exhibits activity against VEGFR2 (IC50=2 nM). This compound retards MLKL membrane translocation and inhibits necroptosis. It is for research use only.
- Potent MLKL inhibitor (Kd of 9.3 μM)
- Active against VEGFR2 (IC50=2 nM)
- Retards MLKL membrane translocation
- Inhibits necroptosis
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Medchemexpress LLC 2(1H)-Isoquinolineacetamide, 3,4-dihydro-6,7-dimethoxy-N-methyl-a-phenyl-1-[2-[4-(trifluoromethy | 913358-93-7 | MFCD22419385 | 100.0% | 549.02 g/mol | C29H32ClF3N2O3 | 25 MG
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Almorexant hydrochloride is the hydrochloride salt of a potent, orally active dual orexin (OX1/OX2) receptor antagonist used in neuroscience research of sleep and arousal mechanisms. It is supplied as a high-purity solid and as a DMSO solution, with batch COA documentation for research use.
- Potent dual orexin receptor antagonist suitable for receptor pharmacology studies
- High purity suitable for in vitro and in vivo experiments
- Available in multiple solid pack sizes and as a DMSO solution
- Certificate of analysis provided for batch-specific quality assurance
- Hydrochloride salt form for improved handling and formulation stability
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Medchemexpress LLC Aprindine hydrochloride | 33237-74-0 | 99.0% | C22H31ClN2 | 5 MG
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Aprindine hydrochloride | 33237-74-0 | 99.0% | C22H31ClN2 | 5 MG
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Medchemexpress LLC Sovesudil hydrochloride | 2984963-50-8 | 99.5% | 443.90 | 25 MG
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Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. It lowers intraocular pressure (IOP) without inducing hyperemia.
- Potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor
- IC50s of 3.7 nM for ROCK-I and 2.3 nM for ROCK-II
- Lowers intraocular pressure (IOP) without inducing hyperemia
- Induces altered cellular behavior of human trabecular meshwork (HTM) cells in vitro
- Effectively reduces IOP in ocular normotensive and acute hypertensive rabbits without causing distinct hyperemia in vivo
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Medchemexpress LLC Berubicin (hydrochloride) | 293736-67-1 | 95.08% | 670.10 | 5 MG
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Berubicin hydrochloride is a Doxorubicin analog capable of crossing the blood-brain barrier. It inhibits P-gp and MRP1-mediated efflux, suppressing glioblastoma multiforme (GBM). This compound exhibits toxic effects on leukemia cells by activating nuclear factor κB (NF-κB) and induces apoptosis in neuroblastoma cells. It is suitable for studying nervous system-related tumors.
- Can cross the blood-brain barrier
- Inhibits P-gp and MRP1-mediated efflux
- Suppresses glioblastoma multiforme (GBM)
- Exerts toxic effects on leukemia cells by activating nuclear factor κB (NF-κB)
- Induces apoptosis in neuroblastoma cells
- Useful in the study of nervous system-related tumors
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Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 25 MG
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EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor with an IC50 of 0.4 nM. This compound reduces levels of H3K79me2 and H3K79me1, leading to a significant down-regulation of HOXA9 and MEIS1 expression. It selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis of leukemia cells, making it suitable for leukemia research.
- Effective and selective DOT1L inhibitor
- Reduces H3K79me2 and H3K79me1 levels
- Down-regulates HOXA9 and MEIS1 expression
- Selectively inhibits MLL rearrangement cell proliferation
- Promotes differentiation and apoptosis of leukemia cells
- Potent DOT1L enzyme activity inhibition (IC50 of 400±100 pM)
- Demonstrates selectivity over other histone methyltransferases (HMTs)
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Medchemexpress LLC Dopexamine hydrochloride | 86484-91-5 | 429.42 | 5 MG
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Dopexamine hydrochloride is a β2 adrenergic receptor agonist and a dopamine analogue with agonist activity at β2 and dopaminergic receptors. It can attenuate systemic inflammatory response, reduce tissue leukocyte infiltration, and protect against organ injury at doses that do not alter global hemodynamics or regional microvascular flow. It also reduces the systemic inflammatory response to endotoxin, including cytokine release, endothelial adhesion molecules, and oxidative stress, without substantially changing systemic hemodynamics.
- β2 adrenergic receptor agonist
- Dopamine analogue with agonist activity at β2 and dopaminergic receptors
- Attenuates systemic inflammatory response
- Reduces tissue leukocyte infiltration
- Protects against organ injury
- Reduces systemic inflammatory response to endotoxin, including cytokine release, endothelial adhesion molecules, and oxidative stress
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Medchemexpress LLC Vatinoxan (hydrochloride) | 130466-38-5 | 99.8% | 454.97 | 50 MG
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Vatinoxan hydrochloride is a peripheral α2 adrenergic receptor antagonist. It is for research use only and may be useful in attenuating reductions in heart rate.
- Increases cardiac index and tissue oxygen delivery without adverse effects.
- Attenuates or prevents dexmedetomidine's systemic hemodynamic effects in a dose-dependent manner.
- Induces the least alterations in cardiovascular function at a 50:1 dose ratio (Vatinoxan:dexmedetomidine).
- Attenuates bradycardia associated with dexmedetomidine.
- Shortens sedative effect without altering its quality.
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